Reply: Array comparative genomic hybridization for the detection of submicroscopic copy number variations of the X chromosome in women with premature ovarian failure
نویسندگان
چکیده
(Shelling, 2000). Of interest is the lower copy number detection rate in our study (4%) compared with the detection rate of 48% in the recent publication by Quilter et al. (2010). Quilter et al. report that one of the 15 women with a CNV had primary amenorrhea. Possibilities to explain the differences in detection rate compared with this study may be differences in the age of onset of POF, or the presence of a positive family history of POF. Quilter et al. (2010) does not provide these demographic details. Further studies in larger numbers of POF patients clinically characterized by age of onset and the presence of a positive family history would help clarify the association between X chromosome CNV and POF.
منابع مشابه
Array comparative genomic hybridization for the detection of submicroscopic copy number variations of the X chromosome in women with premature ovarian failure.
Some of the limits of our study were already mentioned in our original paper, but they are clarified in this letter better. Overall, we thus just thank the authors for their precious and constructive comments. Array comparative genomic hybridization for the detection of submicroscopic copy number variations of the X chromosome in women with premature ovarian failure Sir, Evidence suggests that ...
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